Get to know Tumor-LN-oC in our project video!

During the 4.5 years of the project, Tumor-LN-oC consortium has developed a robust, automated tumor-lymph node-on-chip platform connecting primary surgically removed human tumors and lymph node (LN) tissue from the same cancer patient. This “biological twin” facilitates the study of primary tumor interactions with lymph nodes.

To achieve this, the Tumor-LN-oC platform uses a novel multi-compartment microfluidic chip mimicking the tumor microenvironment and its lymphatic connection. Employing mid-IR Photothermal (MIP) spectroscopy and microlens array-based micro-optics, we can generate spectral “fingerprints” of metastasizing cells for diagnostic purposes. Laser-based bioprinting is used to precisely place LN and tumor cells within the chip with high viability. The platform has been developed at TRL5 and validated with real patient samples, considering regulatory pathways to facilitate market entry. If you’re interested to learn more about the project, check out our project video on Youtube!

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